Effect of Exogenous Testosterone, Finasteride, and Castration on serum level of Thyroxin

نویسندگان

  • Fatemeh Zarei
  • Mozafar Khazaei
  • Namdar Yousofvand
چکیده مقاله:

Background: The secretion of thyroxin (T4) as the main hormone of thyroid gland is regulated by androgens. The present study aimed to evaluate the effect of testosterone and finasteride administration and castration on serum levels of T4 and to show the effect of this regulation on total body weight, weight of testis, and the weight of prostate. Methods: Male adult rats (n = 32) were divided into 4 groups (n = 8): Group 1 (control), Group 2 (castration), Group 3 (finasteride: 20 mg/kg/day) and Group 4 (testosterone: 5 mg/kg/day). At the end of the study (35 days), serum level of thyroxin, body weight, weight of testis, and prostate were determined. Results: The data showed that the body weight increased in castrated (P = 0.04) and decreased in testosterone (P = 0.00) groups but did not differ in finasteride (P>0.05) group. There were not any differences in the weight of testis among control, finasteride, and testosterone groups but the weight of prostate increased in testosterone group (P = 0.00) and decreased in castrated (P = 0.03) and finasteride groups (P = 0.04). In addition, the serum level of T4 (nmo/ml) decreased in the three groups: finasteride (P = 0.03), testosterone (P = 0.04), and castrated (P = 0.00). Conclusion: Testosterone in both high and low levels decreased the amount of T4 with a time-dependent manner.

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منابع مشابه

Effect of exogenous testosterone, finasteride, and castration on serum level of thyroxin.

BACKGROUND The secretion of thyroxin (T4) as the main hormone of thyroid gland is regulated by androgens. The present study aimed to evaluate the effect of testosterone and finasteride administration and castration on serum levels of T4 and to show the effect of this regulation on total body weight, weight of testis, and the weight of prostate. METHODS Male adult rats (n = 32) were divided in...

متن کامل

effect of exogenous testosterone, finasteride, and castration on serum level of thyroxin

background: the secretion of thyroxin (t4) as the main hormone of thyroid gland is regulated by androgens. the present study aimed to evaluate the effect of testosterone and finasteride administration and castration on serum levels of t4 and to show the effect of this regulation on total body weight, weight of testis, and the weight of prostate. methods: male adult rats (n = 32) were divided in...

متن کامل

Effect of Exogenous Testosterone, Finasteride, and Castration on Serum Level of Thyroxine

Background: The secretion of thyroxine (T4) as the main hormone of thyroid gland is regulated by androgens. The present study aimed to evaluate the effect of testosterone and finasteride administration and castration on serum levels of T4 and to show the effect of this regulation on total body weight, weight of testis, and the weight of prostate. Methods: Male adult rats (n = 32) were divided i...

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Exogenous Testosterone, Finasteride and Castration Effects on Testosterone, Insulin, Zinc and Chromium in Adult Male Rats

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Exogenous testosterone, finasteride and castration effects on testosterone, insulin, zinc and chromium in adult male rats.

BACKGROUND Although effects of trace elements on secretion of sex steroids and insulin have been studied, the effects of these hormones on serum level of trace elements have been rarely investigated. The aim of the present study was to evaluate the effect of testosterone and finasteride administration and castration on serum levels of testosterone, insulin, zinc and chromium. METHODS Male adu...

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exogenous testosterone, finasteride and castration effects on testosterone, insulin, zinc and chromium in adult male rats

background: although effects of trace elements on secretion of sex steroids and insulin have been studied, the effects of these hormones on serum level of trace elements have been rarely investigated. the aim of the present study was to evaluate the effect of testosterone and finasteride administration and castration on serum levels of testosterone, insulin, zinc and chromium. methods: male adu...

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عنوان ژورنال

دوره 17  شماره 4

صفحات  221- 224

تاریخ انتشار 2013-10

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